Adult & childn >40 kg 250 mg tid, increase to 500 mg tid for more severe infections. Max: 6 g daily in divided doses.
Severe or recurrent purulent infection of the resp tract 3 g bid.
Simple acute UTI Two 3-g doses w/ 10-12 hr interval.
Dental abscess Two 3 g doses w/ 8 hr interval.
Gonorrhea 3 g as a single dose.
H. pylori eradication 750-1 g bid in combination w/ PPI & antibiotics for 7 days.
Childn <40 kg 125 mg tid.
Severe infections May be increased to 250 mg tid.
Acute otitis media 750 mg bid for 2 days may be used as alternative treatment.
Patients w/ the highest risk of infective endocarditis that require manipulation of the gingival or periapical region of the teeth or perforation of the oral mucosa in adult & childn >40 kg 2 g single oral dose 30-60 min before procedure.
Childn <40 kg 50 mg/kg single oral dose 30-60 min before procedure.
Moderate renal impairment in adult & childn Max: 500 mg bid.
Severe renal impairment Max: 500 mg/day.
Childn <40 kg 15 mg/kg bid (max: 500 mg bid).
Patients receiving peritoneal dialysis Max: 500 mg/day.
Adult receiving hemodialysis 500 mg or 15 mg/kg in childn. 1 additional dose may be administered during dialysis & at end of each dialysis.
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